Doniphan is a very small city located in the state of Missouri. With a population of 1,788 people and two associated neighborhoods, Doniphan is the 293rd largest community in Missouri.

Telecommuters are a relatively large percentage of the workforce: 11.68% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Being a small city, Doniphan does not have a public transit system used by locals to get to and from work.

The education level of Doniphan citizens, measured as those with bachelor's degrees or advanced degrees, is similar to the national average for all American cities and towns. 19.57% of adults 25 and older in Doniphan have a college degree.

The per capita income in Doniphan in 2022 was $19,265, which is low income relative to Missouri and the nation. This equates to an annual income of $77,060 for a family of four. However, Doniphan contains both very wealthy and poor people as well.

Doniphan is a somewhat ethnically-diverse city. The people who call Doniphan home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Doniphan residents report their race to be White, followed by Asian. Important ancestries of people in Doniphan include German, English, Irish, Scots-Irish, and French.

The most common language spoken in Doniphan is English. Other important languages spoken here include Italian and German/Yiddish.