Millsboro is a somewhat small coastal town (i.e. on the ocean, a bay, or inlet) located in the state of Delaware. With a population of 7,426 people and 11 associated neighborhoods, Millsboro is the 12th largest community in Delaware. Much of the housing stock in Millsboro was built relatively recently. The construction of new real estate can often be taken as an indication that the local Millsboro economy is robust, and that jobs or other amenities are attracting an influx of new residents. This seems to be the case in Millsboro, where the median household income is $64,622.00.

Telecommuters are a relatively large percentage of the workforce: 8.07% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Millsboro is also nautical, which means that parts of it are somewhat historic and touch the ocean or tidal bodies of water, such as inlets and bays. Such areas are often places that visitors and locals go for waterfront activities or taking in the scenery.

The population of Millsboro is very well educated relative to most cities and towns in the nation, where the average community has 21.84% of its adult population holding a 4-year degree or higher: 35.07% of adults in Millsboro have a bachelor's degree or even advanced degree.

The per capita income in Millsboro in 2022 was $34,247, which is middle income relative to Delaware and the nation. This equates to an annual income of $136,988 for a family of four. However, Millsboro contains both very wealthy and poor people as well.

Millsboro is an extremely ethnically-diverse town. The people who call Millsboro home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Millsboro residents report their race to be White, followed by Black or African-American. Important ancestries of people in Millsboro include Irish, English, German, Italian, and Scottish.

The most common language spoken in Millsboro is English. Other important languages spoken here include Spanish and Italian.