De Soto is a somewhat small city located in the state of Missouri. With a population of 6,451 people and four associated neighborhoods, De Soto is the 112th largest community in Missouri.

A relatively large number of people in De Soto telecommute to their jobs. Overall, about 11.53% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

One downside of living in De Soto, however, is that residents on average have to contend with a long commute, spending on average 33.47 minutes every day commuting to work.

The citizens of De Soto are slightly less educated than the national average of 21.84% for the average city or town: 13.41% of adults in De Soto have a bachelor's degree or advanced degree

The per capita income in De Soto in 2018 was $24,846, which is middle income relative to Missouri, and lower middle income relative to the rest of the US. This equates to an annual income of $99,384 for a family of four. However, De Soto contains both very wealthy and poor people as well.

De Soto is a somewhat ethnically-diverse city. The people who call De Soto home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of De Soto residents report their race to be White, followed by Asian. Important ancestries of people in De Soto include German, Irish, English, French, and Italian.

The most common language spoken in De Soto is English. Other important languages spoken here include Italian and Polish.